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A-867744 - CAS# 1000279-69-5 terin) 19(23):6519-23

SKU: 87020452447

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Description

19(23):6519-23

Chemical Name: N-(6-dodecanoylnaphthalen-2-yl)-N-methylglycine

CAS Number: 486427-17-2

CAS Number: 7175-09-9

Solubility: DMSO: 125 mg/mL (477

A-867744 - CAS# 1000279-69-5 terin) 19(23):6519-23A 867744 is a type II PAM with good potency and selectivity. A 867744 showed acceptable pharmacokinetic profile across species and brain levels sufficient to modulate alpha7 nAChRs. In a rodent model of sensory gating, A 867744 normalized gating deficits. A 867744 represents a novel class of molecules capable of allosteric modulation of the alpha7 nAChRs. A 867744 potentiated acetylcholine (ACh) evoked currents, with an EC(50) value of approximately 1

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